| Identification | |
| Name: | Trimetrexate glucuronate |
| Synonyms: | 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine D-glucuronate |
| CAS: | 82952-64-5 |
| Molecular Formula: | C19H23N5O3.C6H10O7 |
| Molecular Weight: | 563.56 |
| InChI: | InChI=1/C19H23N5O3.C6H10O7/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3;7-1-2(8)3(9)4(10)5(11)6(12)13/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24);1-5,8-11H,(H,12,13)/t;2-,3+,4-,5-/m.0/s1 |
| Molecular Structure: | ![(C19H23N5O3.C6H10O7) 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine D-glucuronate](https://img.guidechem.com/structureimg/82952-64-5.gif) |
| Properties | |
| Density: | 1.305 g/cm3 |
| Biological Activity: | Potent lipophilic inhibitor of dihydrofolate reductase (DHFR) that displays antineoplastic and antiprotozoal properties. Inhibits protozoal, bacterial and human DHFR with IC 50 values of 1.4, 6.1 and 3.2 nM respectively. Affects G 1 /S phase cell cycle progression. |
| Safety Data | |
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