N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE (853625-60-2)

Identification
Name:	N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE
Synonyms:	N-[4-[5-(1,3-BENZODIOXOL-5-YL)-3-METHOXY-1H-1,2,4-TRIAZOL-1-YL]PHENYL]-2-(PHENYLTHIO)ACETAMIDE;SECINH3
CAS:	853625-60-2
Molecular Formula:	C24H20N4O4S
Molecular Weight:	0
Molecular Structure:
Properties
Biological Activity:	Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC 50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μ M for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.
Safety Data

Other Product

Acetamide,N-[4-[5-[(aminocarbonyl)amino]-1H-1,2,4-triazol-3-yl]phenyl]-, hydrate (2:1)
Ethanone,2-[[3-(1,3-benzodioxol-5-yl)-1H-1,2,4-triazol-5-yl]thio]-1-(4-methylphenyl)-
Ethanone,2-[[3-(1,3-benzodioxol-5-yl)-1H-1,2,4-triazol-5-yl]thio]-1-(4-bromophenyl)-
Ethanone,2-[[5-(1,3-benzodioxol-5-yl)-1H-1,2,4-triazol-3-yl]thio]-1-(4-chlorophenyl)-
Ethanone,2-[[5-(1,3-benzodioxol-5-yl)-1H-1,2,4-triazol-3-yl]thio]-1-(4-nitrophenyl)-
Ethanone,2-[[5-(1,3-benzodioxol-5-yl)-1H-1,2,4-triazol-3-yl]thio]-1-(4-methoxyphenyl)-
1H-Indole-3-acetamide,6-(aminocarbonyl)-a-1,3-benzodioxol-5-yl-N-[(2-methoxy-4-methylphenyl)sulfonyl]-1-methyl-
1H-Indole-3-acetamide,a-1,3-benzodioxol-5-yl-6-(hydroxymethyl)-N-[(2-methoxy-4-methylphenyl)sulfonyl]-1-methyl-
1H-Indole-3-acetamide,a-1,3-benzodioxol-5-yl-6-fluoro-N-[(2-methoxy-4-methylphenyl)sulfonyl]-1-methyl-
1H-Indole-3-acetamide,a-1,3-benzodioxol-5-yl-6-chloro-N-[(2-methoxy-4-methylphenyl)sulfonyl]-1-methyl-
1H-Indole-3-acetamide,a-1,3-benzodioxol-5-yl-6-cyano-N-[(2-methoxy-4-methylphenyl)sulfonyl]-1-methyl-
1H-Indole-3-acetamide,a-1,3-benzodioxol-5-yl-6-(methoxymethyl)-N-[(2-methoxy-4-methylphenyl)sulfonyl]-1-methyl-
Acetamide, N-[4-[3-(1,3-benzodioxol-5-yl)-1-oxo-2-propenyl]phenyl]-
Acetamide,N-[4-(5-amino-2-phenyl-4-oxazolyl)-1-phenyl-1H-1,2,3-triazol-5-yl]-
Acetamide,N-[2-[5-(3-chloro-4-methoxyphenyl)-3-phenyl-1H-1,2,4-triazol-1-yl]ethyl]-N-cyclopentyl-
N-[3-[3-Fluoro-4-(1,2,3-triazol-1-yl)phenyl]-2-oxooxazolidin-5(S)-ylmethyl]acetamide
N-[3-[4-[1-(Ethoxymethyl)-4-(4-fluorophenyl)-1H-1,2,3-triazol-5-yl]pyrimidin-2-yloxy]phenyl]acetamide
Acetamide,2-[(4,5-dihydro-5-oxo-4-pentyl-1H-1,2,4-triazol-3-yl)thio]-N-[4-(1-methylethyl)phenyl]-
Acetamide,N-[4-(5-amino-1H-1,2,4-triazol-3-yl)phenyl]-, hydrate (1:1)
Acetamide,2-methoxy-N-[3-[1-(tetrahydro-2H-pyran-2-yl)-5-[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]-1H-indazol-3-yl]phenyl]-