| Identification |
| Name: | Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine,1,2,3,4,10,14b-hexahydro-2-methyl- |
| Synonyms: | 6-Azamianserin;Avanza;Mepirzapin;Mepirzepine;Mirtaz 15;Mirtazepine;Mirtazipine;Norset;Org 3770;Promyrtil;Remergil;Remergon;Remeron;Remeron SolTab;Rexer;Zispin;2-methyl-1,2,3,4,10,14b-hexahydropyrazino[2,1-a]pyrido[2,3-c][2]benzazepine;Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl-; |
| CAS: | 85650-52-8 |
| EINECS: | 288-060-6 |
| Molecular Formula: | C17H19N3 |
| Molecular Weight: | 265.35286 |
| InChI: | InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3 |
| Molecular Structure: |
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| Properties |
| Density: | 1.22g/cm3 |
| Water Solubility: | DMSO: ~8 mg/mL, soluble |
| Solubility: | DMSO: ~8 mg/mL, soluble |
| Appearance: | white solid |
| Biological Activity: | Antidepressant agent; potent 5-HT 2 , 5-HT 3 and histamine H 1 receptor antagonist and moderately potent α 2 -adrenoceptor antagonist (pK i values are 8.05, ~ 8.1, 9.3 and 6.95 respectively). Enhances noradrenalin (NA) release in rat brain via inhibition of α 2 -adrenergic autoreceptors and displays only weak affinity for monoamine transporters (pK i values are 5.6, < 5 and < 5.1 for inhibition of NA, dopamine and 5-HT uptake respectively). Increases hippocampal NA and 5-HT levels in rats following systemic administration in vivo . |
| Storage Temperature: | Store at RT |
| Color: | white |
| Safety Data |
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