| Identification |
| Name: | Pyrazolo[1,5-a]pyrimidine,6-[4-[2-(1-piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)- |
| Synonyms: | Compound C;Dorsomorphin |
| CAS: | 866405-64-3 |
| Molecular Formula: | C24H25 N5 O |
| Molecular Weight: | 399.4882 |
| InChI: | InChI=1/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2 |
| Molecular Structure: |
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| Properties |
| Density: | 1.255g/cm3 |
| Refractive index: | 1.67 |
| Biological Activity: | Potent and selective inhibitor of AMP-activated protein kinase (AMPK) (K i = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKC θ , PKA and JAK3. Inhibits AMPK activation induced by AICAR and metformin. Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro . |
| Storage Temperature: | 2-8°C |
| Safety Data |
| Hazard Symbols |
Xn: Harmful
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