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Hydroxypropyl cellulose (9004-64-2)

Identification
Name:Hydroxypropyl cellulose
Synonyms:Cellulose,ethers,2-hydroxypropyl ether;Klucel 99GF-EP;L-HPC-LH 21;Klucel LF;L-HPC-LH 41;L-HPC LH 11;JK 491;Klucel HW;Klucel MF;Klucel G;Klucel KL;HPC-MG;EF 10 (cellulose derivative);Klucel E;Klucel SR;Cellulose,polymerspolymer with methyloxirane ;; see;Klucel M;PM 50 (polymer);HPC-EF-G;HPC-MF;Klucel H;Fuji HEC-SG 25F;also Cellulose,ethers,2-hydroxypropyl ether;Nisso HPC;Klucel;HPC-L;HPC-S;LHPC 21;HPC-M;Klucel EEL;Klucel HXF;Metolose LE-G;G 4000HXL;HPC-H;Klucel Gf;TSK-Gel G 2000HXL;L-HPC-LH 31;HPC-E (cellulose derivative);Klucel 99E;Klucel 99G;HPC-SL;Nisso HPC-L;Klucel JF;Klucel L;Nisso HPC-SL;LH 31;Klucel J;Klucel EF;Klucel HF;HPC-LG;Klucel 99M;L-HPC-LH 22;Klucel HF-NF;HPC-LE-G;Hyprolose;L-HPC;High-Substituted Hydroxyproxyl Cellulose(H-HPC);Hydroxy Propyl Cellulose;Hydroxypropylcellulose;HYDROXYPROPYL ETHER of CELLULOSE;Hydroxypropyl cellulose,9004-64-2;Hydroxypropyl Cellulose(HPC);
CAS:9004-64-2
EINECS: 220-971-6
Molecular Formula: C36H70O19
Molecular Weight: 576.762
InChI: InChI=1/C36H70O19/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41/h19-44H,9-18H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27?,28?,29?,30-,31?,32?,33?,34?,35?,36+/m1/s1
Molecular Structure: (C36H70O19) Cellulose,ethers,2-hydroxypropyl ether;Klucel 99GF-EP;L-HPC-LH 21;Klucel LF;L-HPC-LH 41;L-HPC LH 11;...
Properties
Density:1.27 g/cm3
Stability:Stable. Incompatible with strong oxidizing agents. Combustible.
Refractive index:1.531
Appearance:white powder
Specification:

The Hydroxypropyl cellulose, with the cas registry number 9004-64-2, has the systematic name of Cellulose, 2-hydroxypropyl ether. Its product categories are various, including Cellulose; Natural Polymers; Polymer Science; HU - HZPolymer Standards; Hydroxypropyl cellulose; Water Soluble Polymers; Alphabetic; H; API's. What's more, this chemical could be produced by the reaction of alkali and epoxypropane. 

This is a kind of white particle or fabrous powder with no odour but with thermoplasticity. It is soluble in ehanol while insoluble in diethyl ether and could become transparent to oyster white viscoloid colloidal solution. Besides, this chemical is stable chemically but combustible and incompatible with strong oxidizing agents. While using this chemical, please do avoid contacting with skin and eyes.

As to its usage, it is widely applied in many fields. It could be usually used in pharmaceutic for being the cementing agent and membrance-forming agent in medicines; It could also be used as the film-forming agent, dispersing agent, stabilizing agent and thickening agent in cosmetic, painting and printing ink industries.

Additionally, you could convert the following datas into the molecular structure:
Smiles: O([C@H]1[C@@H]([C@H]([C@@H](*)O[C@@H]1COC(C)C)OC(C)C)OC(C)C)[C@H]1[C@@H]([C@H]([C@H](O*)[C@H](O1)COC(C)C)OC(C)C)OC(C)C

Below are the toxicity information of this chemical which have been tested:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 25gm/kg (25000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
mouse LD50 intravenous > 500mg/kg (500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
rat LD50 intraperitoneal > 25gm/kg (25000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
rat LD50 intravenous 250mg/kg (250mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
rat LD50 oral 10200mg/kg (10200mg/kg)   FAO Nutrition Meetings Report Series. Vol. 46A, Pg. 131, 1969.

Report:

The Hydroxypropyl cellulose, with the cas registry number 9004-64-2, has the systematic name of Cellulose, 2-hydroxypropyl ether. Its product categories are various, including Cellulose; Natural Polymers; Polymer Science; HU - HZPolymer Standards; Hydroxypropyl cellulose; Water Soluble Polymers; Alphabetic; H; API's. What's more, this chemical could be produced by the reaction of alkali and epoxypropane. 

This is a kind of white particle or fabrous powder with no odour but with thermoplasticity. It is soluble in ehanol while insoluble in diethyl ether and could become transparent to oyster white viscoloid colloidal solution. Besides, this chemical is stable chemically but combustible and incompatible with strong oxidizing agents. While using this chemical, please do avoid contacting with skin and eyes.

As to its usage, it is widely applied in many fields. It could be usually used in pharmaceutic for being the cementing agent and membrance-forming agent in medicines; It could also be used as the film-forming agent, dispersing agent, stabilizing agent and thickening agent in cosmetic, painting and printing ink industries.

Additionally, you could convert the following datas into the molecular structure:
Smiles: O([C@H]1[C@@H]([C@H]([C@@H](*)O[C@@H]1COC(C)C)OC(C)C)OC(C)C)[C@H]1[C@@H]([C@H]([C@H](O*)[C@H](O1)COC(C)C)OC(C)C)OC(C)C

Below are the toxicity information of this chemical which have been tested:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal > 25gm/kg (25000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
mouse LD50 intravenous > 500mg/kg (500mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
rat LD50 intraperitoneal > 25gm/kg (25000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
rat LD50 intravenous 250mg/kg (250mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 4, Pg. 1013, 1970.
rat LD50 oral 10200mg/kg (10200mg/kg)   FAO Nutrition Meetings Report Series. Vol. 46A, Pg. 131, 1969.

Storage Temperature: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
Usage:Used as a emulsifier, stabilizer, whipping aid, protective colloid, film former or thickener in foods.
Safety Data
 

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