Hemoglobins (9008-02-0)

 Hemoglobins , with the CAS registry number is 9008-02-0, is also named as Blood pigments ; Hemoglobin ; Deoxyhemoglobins ; Ferrohemoglobins ; Hemoglobin human . It must storage at 2-8 °C. 

 Hemoglobin is the tissues of some invertebrates and the iron-containing oxygen-transport metalloprotein in the red blood cells of vertebrates. Hemoglobin transports oxygen from the lungs or gills to the rest of the body, then  it releases the oxygen for cell use. Hemoglobin is also found outside red blood cells and their progenitor lines.

 Hemoglobin which is also called Hb is synthesized in a series of steps. In the mitochondria and the cytosol of immature red blood cells, the heme part is synthesized in a series of steps, while the ribosomes in the cytosol synthesize the globin protein parts. Production of Hb continues in the cell throughout its early development from the proerythroblast to the reticulocyte in the bone marrow. At this point, in mammalian red blood cells, the nucleus is lost,  but it is not in birds and many other species. Even after the loss of the nucleus in mammals, residual ribosomal RNA allows further synthesis of Hb until the reticulocyte loses its RNA soon after entering the vasculature (this hemoglobin-synthetic RNA in fact gives the reticulocyte its reticulated appearance and name).

In 1840, Hünefeld discovered the hemoglobin. Otto Funke published a series of articles in 1851. In these articles, he described growing hemoglobin crystals by successively diluting red blood cells with a solvent such as pure water, alcohol or ether, followed by slow evaporation of the solvent from the resulting protein solution. A few years later, Hemoglobin's reversible oxygenation was described by Felix Hoppe-Seyler. Max Perutz used X-ray crystallography to determine the molecular structure of hemoglobin in 1959. The name hemoglobin is the portmanteau of heme and globin. The role of hemoglobin in the blood was elucidated by physiologist Claude Bernard.