| Identification | |
| Name: | Bicalutamide |
| CAS: | 90357-06-5 |
| Molecular Formula: | C18H14F4N2O4S |
| Molecular Weight: | 430.373373 |
| InChI: | InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25) |
| Molecular Structure: | ![(C18H14F4N2O4S) (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamide...](https://img.guidechem.com/casimg/90357-06-5.gif) |
| Properties | |
| Transport: | OTH |
| Density: | 1.52 g/cm3 |
| Refractive index: | 1.577 |
| Water Solubility: | Insoluble in water |
| Solubility: | Insoluble in water |
| Appearance: | off-white crystalline solid |
| Specification: |
?Bicalutamide , its cas register number is 90357-06-5. It also can be called?Bicalutamide [USAN:INN:BAN]?; (+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide ; BRN 5364666 ; CCRIS 8728 ; Casodex ; HSDB 7655 ; ICI 176334 ; UNII-A0Z3NAU9DP ; Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)- .It is a?off-white crystalline solid. It??is practically insoluble in water. |
| Packinggroup: | III |
| HS Code: | 29242995 |
| Biological Activity: | Orally active non-steroidal androgen receptor antagonist (IC 50 = 190 nM). Displays peripheral selectivity and does not effect serum levels of LH and testosterone. Exhibits potent anticancer activity in vivo . |
| Storage Temperature: | Store in original container in a cool dark place. |
| Color: | Crystals from 1:1 (v/v) mix of ethyl acetate and petroleum ether Fine white to off-white powder [FDA; Casodex. Oct 25, 2004. Washington, DC: Food Drug Admin. Available from, as of Oct 14, 2008: http://www.fda.gov/medwatch/SAFETY/2005/MAY_PI/Casodex_PI.pdf ] **UNREVIEWED** |
| Usage: | Non-steroidal peripherally active antiandrogen. Used as an antiandrogen, antineoplastic (hormonal) |
| Safety Data | |
| Hazard Symbols |
Xi: Irritant
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