| Identification |
| Name: | Benzoic acid,4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]- |
| Synonyms: | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoicacid;N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl)-2-naphthyl)terephthalamic acid;Am 80 (pharmaceutical);Amnolake;NSC 608000;Retinoid AM 80; |
| CAS: | 94497-51-5 |
| Molecular Formula: | C22H25NO3 |
| Molecular Weight: | 351.44 |
| InChI: | InChI=1/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26) |
| Molecular Structure: |
![(C22H25NO3) 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoicacid;N-(5,6,7,8-Tetrahydr...](https://img.guidechem.com/casimg/94497-51-5.gif) |
| Properties |
| Density: | 1.154g/cm3 |
| Refractive index: | 1.593 |
| Appearance: | crystalline solid |
| Biological Activity: | Retinoic acid receptor α (RAR α ) agonist that induces differentiation (ED 50 = 0.79 nM) and apoptosis of HL-60 cells in vitro . Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μ M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo . |
| Usage: | Synthetic retinoic acid receptor-a/?selective retinoid. Antineoplastic |
| Safety Data |
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