| Identification | |
| Name: | Troglitazone |
| Synonyms: | (+/-)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione |
| CAS: | 97322-87-7 |
| Molecular Formula: | C24H27NO5S |
| Molecular Weight: | 441.54 |
| InChI: | InChI=1/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28) |
| Molecular Structure: | ![(C24H27NO5S) (+/-)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione](https://img.guidechem.com/casimg/97322-87-7.gif) |
| Properties | |
| Melting Point: | 184-186°C |
| Flash Point: | 351.2°C |
| Boiling Point: | 657°Cat760mmHg |
| Density: | 1.266g/cm3 |
| Stability: | This material is stable if stored as directed. |
| Solubility: | Insoluble |
| Appearance: | Yellow solid. |
| Specification: |
Troglitazone ,its CAS NO. is 97322-87-7,the synonyms is (+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione ; 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)- ; 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione ; BRN 4338399 ; CCRIS 8969 ; CI 991 ; CS 045 ; GR 92132X ; Prelay ; Rezulin ; Romglizone ; UNII-I66ZZ0ZN0E . |
| Biological Activity: | Selective PPAR γ receptor agonist (EC 50 values are 780 and 555 nM at murine and human PPAR γ receptors respectively). Displays no activity at PPAR α or PPAR δ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits lamellipodia formation and actin polymerization. |
| Flash Point: | 351.2°C |
| Storage Temperature: | This product should be stored at room temperature. It should be kept in a tightly closed container. |
| Color: | white to yellow |
| Usage: | An oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production |
| Safety Data | |
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