| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam. | |
| [Ingestion] Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. | |
| [Inhalation] Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask. | |
| [Skin] Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. | |
| [Eyes] Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. | |
| [Storage] Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. | |
| [Handling] Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. | |
| [Inhalation] May cause respiratory tract irritation. May cause thryoid effects. May cause liver damage. | |
| [Skin] May cause skin irritation. | |
| [Eyes] May cause eye irritation. | |
| [Ingestion] Harmful if swallowed. May cause irritation of the digestive tract. May cause liver damage. May cause thyroid abnormalities. Human fatalities have been reported from acute poisoning. | |
| [Personal Protection] Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. | |
| [Respirators] Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. | |
| [Exposure Effects] Chronic exposure may cause liver damage. Chronic exposure may cause thyroid damage: thyroid enlargement, decrease in metabolic rate, and hypothyroidism. Reproductive effects have been reported in humans. | |
| [Appearance] White powder. | |
| [Solubility in water] Insoluble | |
| [Melting Point] 146 | |
| [pKa/pKb] 7.46 (pKb) | |
| [Usage] Antifungal, antineoplastic, antiadrenal. | |
| [Product Name] cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine | |
| [Synonyms] 1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone Fungoral Nizoral Nizral Piperazine, 1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-, rel- R 41400 | |
| [CAS] "CASEN_65277-42-1.htm">65277-42-1 | |
| [Formula] C26H28Cl2N4O4 | |
| [Molecular Weight] 531.44000000000005 | |
| [EINECS] 265-667-4 | |
| [RTECS] TK7912300 | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector; Human Data | |
| [Merck] 12,5313 | |
| [Beilstein/Gmelin] 4303081 | |
| [Small spills/leaks] Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. | |
| [Incompatibilities] Oxidizing agents. | |
| [Stability] Stable at room temperature in closed containers under normal storage and handling conditions. | |
| [Decomposition] Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. |
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