| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | |
| [Exposure Effects] with therapeutic use - malaise, fatigue, tremors, lack of coordination, abnormal gait, ataxia, dizziness, and/or paresthesia can occur in up to 4-9% of patients receiving amiodarone. Symmetrical peripheral neuropathy has been described with or without accompanying tremors following doses of 600 to 2000 mg per day. A case report also describes a patient with pseudotumor cerebri thought due to amiodarone. | |
| [pKa/pKb] 6.6 (pKa) | |
| [Usage] Medication. | |
| [Product Name] Amiodarone | |
| [Synonyms] (2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone 2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl) benzofuran 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone | |
| [CAS] "CASEN_1951-25-3.htm">1951-25-3 | |
| [Formula] C25H29I2NO3 | |
| [Molecular Weight] 645.32000000000005 | |
| [EINECS] 217-772-1 | |
| [RTECS] OB1360000 | |
| [RTECS Class] Drug; Human Data | |
| [Merck] 12,504 | |
| [Beilstein/Gmelin] 1271711 | |
| [Beilstein Reference] 5-18-02-00353 | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] No data. | |
| [Incompatibilities] Strong oxidizing agents. |
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