| [Flash Point] 155 | |
| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. | |
| [Ingestion] Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended. | |
| [Inhalation] If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention. | |
| [Skin] Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. | |
| [Eyes] If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Inhalation] Apnea has developed secondary to seizures following overdose. - Pulmonary infiltrates with eosinophilia has occurred with chronic therapeutic use. Bronchoconstriction and asthma has been reported after initial dosing. | |
| [Skin] Photosensitivity and pseudoporphyria has been described in chronic therapeutic use. Necrotizing vasculitis has been reported with short term use. | |
| [EC Risk Phrase] R 22 36/37/38 | |
| [EC Safety Phrase] S 26 36/37/39 | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Use NIOSH/MSHA approved respirator appropriate for exposure of concern. | |
| [Exposure Effects] CNS depression and seizures (focal and generalized) have occurred following overdose. A. Dizziness and dystonic movement disorders have also been reported. With therapeutic use - aseptic meningitis has been associated with naproxen. Naproxen is pregnancy category B. <br> 1. Risk Factor D if used in 3rd trimester or near delivery. <br>Because of known effects of the fetus (closure of ductus arteriosus), it should be avoided during late pregnancy. <br>Naproxen has been found in the milk of lactating women; however, The American Academy of Pediatrics considers naproxen to be compatible with breast feeding (Briggs et al, 1998). | |
| [Appearance] Crystals from acetone-hexane. Practically odorless. | |
| [Solubility in water] Insoluble | |
| [Melting Point] 156 | |
| [Boiling Point] 404 | |
| [Vapor Pressure] 3E-7 (25 C) | |
| [pKa/pKb] 4.15 (pKa) | |
| [Partition Coefficient] 3.24 | |
| [Heat Of Vaporization] 69.1 kJ/mol | |
| [Usage] Anti-inflammatory drug. | |
| [Product Name] (+)-2-(6-Methoxy-2-naphthyl)-propionic acid | |
| [Synonyms] (1)-2-(6-Methoxy-2-naphthyl)propionic acid 2-(6-Methoxynaphthalen-2-yl)propanoic acid Cg 3117 Diocodal Dysmenalgit n Naphthaleneacetic acid, 6-methoxy-.alpha.-methyl-, (S)- | |
| [CAS] "CASEN_22204-53-1.htm">22204-53-1 | |
| [Formula] C14H14O3 | |
| [Molecular Weight] 230.26 | |
| [EINECS] 244-838-7 | |
| [RTECS] UF5275000 | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector; Human Data | |
| [Merck] 12,6504 | |
| [Beilstein/Gmelin] 3591067 | |
| [Small spills/leaks] Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces. | |
| [Stability] No data. | |
| [Incompatibilities] Strong oxidizing agents. |
Print