| [Fire Fighting] Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Non-combustible, substance itself does not burn but may decompose upon heating to produce irritating, corrosive and/or toxic fumes. Extinguishing media: Substance is noncombustible; use agent most appropriate to extinguish surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam. | |
| [Fire Potential] This compound is probably combustible. | |
| [Ingestion] Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. | |
| [Inhalation] Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. | |
| [Skin] Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. | |
| [Eyes] Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. | |
| [Storage] Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. | |
| [Handling] Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse. | |
| [Inhalation] Causes respiratory tract irritation. May cause allergic respiratory tract irritation. Can produce delayed pulmonary edema. | |
| [Skin] Causes skin irritation. May cause an allergic reaction in certain individuals. | |
| [Eyes] Causes eye irritation. May cause chemical conjunctivitis. | |
| [Ingestion] May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Human fatalities have been reported from acute poisoning. | |
| [Personal Protection] Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. | |
| [Respirators] A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use. | |
| [Exposure Effects] Prolonged or repeated exposure may cause adverse reproductive effects. Repeated exposure may cause allergic respiratory reaction (asthma). Effects may be delayed. May cause allergic skin reaction in some individuals. | |
| [Appearance] Orange-red thin needles. | |
| [Melting Point] 204 | |
| [Partition Coefficient] -.8 | |
| [Usage] Chemotherapeutic agent for the management of a variety of neoplasms. | |
| [Product Name] (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride | |
| [Synonyms] 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S,10S)- Adriamycin Adriblastina RD Lipodox | |
| [CAS] "CASEN_25316-40-9.htm">25316-40-9 | |
| [Formula] C27H30ClNO11 | |
| [Molecular Weight] 580.03 | |
| [EINECS] 246-818-3 | |
| [RTECS] QI9295900 | |
| [RTECS Class] Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data | |
| [Beilstein/Gmelin] 4229251 | |
| [Small spills/leaks] Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation. | |
| [Stability] Stable at room temperature in closed containers under normal storage and handling conditions. | |
| [Incompatibilities] Strong oxidizing agents. | |
| [Decomposition] Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. |
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