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Demecarium bromide

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[Fire Fighting]

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.
[Ingestion]

Induction of vomiting is usually not necessary due to spontaneous vomiting. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents. Bethanechol - for substantial ingestions of bethanechol, consider gastric lavage preceded by endotracheal intubation. Other agents - carbachol, acetylcholine, and pilocarpine are liquids, rapidly absorbed and probably not removed significantly by gastric emptying procedures. Atropine sulfate is the drug of choice. For significant muscarinic symptoms administer: adults - 2 to 4 mg iv, repeated every 3 to 60 minutes as needed to control symptoms, then prn for 24 to 48 hours. Child - 0.04 To 0.08 Mg/kg iv (up to 4 mg) repeated every 5 to 60 minutes as necessary. Epinephrine - may assist in overcoming severe cardiovascular or bronchoconstrictor responses (dose: 0.1 To 1.0 Mg sc).
[Inhalation]

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.
[Skin]

Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician should examine the area if irritation or pain persists.
[Eyes]

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.
[Storage]

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
[Handling]

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.
[Ingestion]

Nausea, vomiting, abdominal pain, diarrhea, or belching may be noted.
[Inhalation]

Dyspnea, bronchospasm, tachypnea, increased bronchial secretions, and pulmonary edema may occur, especially in asthmatic patients.
[Personal Protection]

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.
[Respirators]

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.
[Melting Point]

164 - 170
[Usage]

Medication.
[Product Name]

Demecarium bromide
[Synonyms]

(m-Hydroxyphenyl)trimethylammonium bromide decamethylenebis[methylcarbamate]
Frumtosnil
Humorsol
Tosmicil
Trimethyl-[3-[methyl-[10-[methyl-(3-trimethylazaniumylphenoxy)carbonylamino]decyl]carbamoyl]oxyphenyl]azanium dibromide
Visumatic
[CAS]

"CASEN_56-94-0.htm">56-94-0
[Formula]

C32H52Br2N4O4
[Molecular Weight]

716.6
[EINECS]

200-301-9
[RTECS]

BR3130000
[RTECS Class]

Other
[Merck]

12,2936
[Beilstein/Gmelin]

3880925
[Beilstein Reference]

4-13-00-00968
[Small spills/leaks]

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.
[Stability]

No data.
[Incompatibilities]

Strong oxidizing agents.