| [Fire Fighting] Fires involving this material can be controlled with a carbon dioxide, dry chemical or Halon extinguisher. | |
| [Fire Potential] This material is probably combustible. | |
| [Ingestion] DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. | |
| [Inhalation] IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used. | |
| [Skin] IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. | |
| [Eyes] First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Inhalation] Noncardiogenic pulmonary edema after hydrochlorothiazide ingestion has been reported and is believed to be an idiosyncratic reaction. | |
| [Personal Protection] Wear self-contained breathing apparatus. | |
| [Respirators] Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. | |
| [Exposure Effects] in overdose lethargy and coma have been reported in children ingesting thiazide diuretics. Altered mental status, headache, hypertonia, muscle weakness, and seizures may develop secondary to diuretic-induced electrolyte abnormalities. Ototoxicity occurs rarely and is usually reversible. | |
| [Appearance] Crystals; white powder. | |
| [Melting Point] 358.5 | |
| [Boiling Point] 410 | |
| [pKa/pKb] 6.85 (pKa) | |
| [Partition Coefficient] -.24 | |
| [Usage] Diuretic sodium salt. | |
| [Product Name] Chlorothiazide | |
| [Synonyms] 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide Alurene Chlorosal Chlorothiazid Chlorthiazide Chlortiazid | |
| [CAS] "CASEN_58-94-6.htm">58-94-6 | |
| [Formula] C7H6ClN3O4S2 | |
| [Molecular Weight] 295.73 | |
| [EINECS] 200-404-9 | |
| [RTECS] DK9450000 | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector | |
| [Merck] 12,2221 | |
| [Beilstein/Gmelin] 34611 | |
| [Beilstein Reference] 4-27-00-08036 | |
| [Small spills/leaks] If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. | |
| [Stability] No data. |
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