| [Fire Fighting] Evacuate area. Wear SCBA and protective clothing. Use agent most suitable for extinguishing surrounding fire. | |
| [Ingestion] Flush mouth out with water. Seek medical attention. | |
| [Inhalation] Remove to fresh air. | |
| [Skin] Flush with copious amounts of water for at least 15 minutes. | |
| [Eyes] Flush with copious amounts of water for at least 15 minutes. | |
| [Storage] store in a tightly closed container. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Inhalation] Allergic reaction. Irritation. | |
| [Skin] Skin hyperpigmentation has been reported. | |
| [Eyes] Irritation. | |
| [Ingestion] Nausea, vomiting, epigastric burning, and abdominal discomfort have been noted. Tetracycline and doxycycline have been implicated in causing esophageal ulceration, but this is thought to be uncommon. | |
| [Personal Protection] Rubber or vinyl gloves, safety goggles and appropriate laboratory clothings. | |
| [Respirators] NIOSH approved respirator. | |
| [Exposure Effects] Headache, papilledema and benign intracranial hypertension have been reported. Maternal ingestion of tetracyclines during pregnancy may cause tooth discoloration, enamel defects, and other congenital anomalies. <br>Hepatotoxicity, pancreatitis, and renal failure may occur in pregnant women following ingestion of tetracyclines during pregnancy. | |
| [Appearance] Yellow, crystalline powder with slight ethanolic odor. | |
| [Solubility in water] Slightly soluble | |
| [Vapor Pressure] 2E-24 (25 C) | |
| [pKa/pKb] 4.50 (pKa) | |
| [Partition Coefficient] -.26 | |
| [Usage] Medication. | |
| [Product Name] Doxycycline | |
| [Synonyms] (4S,4aR,5S,5aR,6R,12aS)-4-(dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 6-Deoxy-5-hydroxytetracycline 6-Deoxytetracycline alpha-6-Deoxy-5-hydroxytetracycline alpha-6-Deoxyoxytetracycline Doxycyclin hyclate | |
| [CAS] "CASEN_564-25-0.htm">564-25-0 | |
| [Formula] C22H24N2O8 | |
| [Molecular Weight] 444.44 | |
| [EINECS] 209-271-1 | |
| [RTECS] QI8650000 | |
| [RTECS Class] Drug; Mutagen; Reproductive Effector; Human Data | |
| [Merck] 12,3496 | |
| [Beilstein/Gmelin] 2230419 | |
| [Small spills/leaks] Wear dust respirator and rubber gloves. Sweep up, avoiding dust generation. Place in appropriate container for disposal. | |
| [Stability] Stable at normal temperatures and pressures. | |
| [Decomposition] Toxic fumes. |
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