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Itraconazole

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[Fire Fighting]

Extinguish with carbon dioxide, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Wear self-contained respirator. Wear fully protective impervious suit.
[Ingestion]

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.
[Inhalation]

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
[Skin]

Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
[Eyes]

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs.
[Storage]

Keep container tightly closed. Keep container in a cool, well-ventilated area.
[Inhalation]

May cause irritation.
[Skin]

May cause irritation.
[Eyes]

May cause irritation.
[Ingestion]

May cause nausea or upset stomach, abdominal cramps, vomiting, diarrhea or loose stools. May affect the liver (jaundice/hepatitis, liver function tests impaired). Symptoms may include dermatitis (skin rash/itching), yellow eyes, dark urine, loss of appetite, vertigo, headache, dizziness, depression, paraesthesias, loss of libido, edema (swelling) of the legs or feet, confusion, weakness, excessive tiredness, shortness of breath, cough. It may also cause hypertension, heart failure. It may affect the blood (changes in serum composition), liver, metabolism (weight loss or anorexia, hypokalemia or loss of potassium), and adrenal gland.
[EC Risk Phrase]

R: 22
[EC Safety Phrase]

S: 2 46
[Personal Protection]

Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
[Exposure Effects]

May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.
[Appearance]

Brown powder.
[Solubility in water]

Insoluble
[Melting Point]

166.2
[Density]

1.40 g/cm3 (20 C)
[pKa/pKb]

7.53 (pKb)
[Partition Coefficient]

4.35
[Usage]

A triazole antifungal agent.
[Product Name]

2-Butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl methyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
[Synonyms]

3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)- 1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-
Canditral
Oriconazole
Orungal
Sporamelt
Triasporin
[CAS]

"CASEN_84625-61-6.htm">84625-61-6
[Formula]

C35H38Cl2N8O4
[Molecular Weight]

705.64
[RTECS]

XZ5481000
[Merck]

12,5262
[Beilstein/Gmelin]

6042047
[Small spills/leaks]

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.
[Stability]

Stable if stored as directed.