| Identification | |
| Name: | milrinone |
| CAS: | 78415-72-2 |
| EINECS: | 278-903-6 |
| Molecular Formula: | C12H9N3O |
| Molecular Weight: | 211.21936 |
| InChI: | InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16) |
| Molecular Structure: |  |
| Properties | |
| Transport: | UN 2811 |
| Melting Point: | >3000C |
| Density: | 1.28 g/cm3 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| Water Solubility: | DMSO: >10 mg/mL |
| Solubility: | DMSO: >10 mg/mL |
| Appearance: | Off-white solid |
| Specification: |
?Milrinone , its cas register number is 78415-72-2. It also can be called 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile ; Milrinonum ; and (3,4'-Bipyridine)-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo- . It? is a phosphodiesterase III inhibitor, and enhances relaxation of the left ventricle by increasing Ca2+-ATPase activity on the cardiac sarcoplasmic reticulum. |
| Packinggroup: | III |
| Biological Activity: | Potent cAMP phosphodiesterase inhibitor (IC 50 = 56 nM for inhibition of PDE III). Has inotropic and vasodilator effects following oral or intravenous administration in vivo . Also available as part of the Phosphodiesterase Inhibitor Tocriset? . |
| Color: | off-white |
| Usage: | Selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic |
| Safety Data | |
| Hazard Symbols |
T:Toxic
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