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6-Thioguanine

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[Fire Fighting]

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.
[Fire Potential]

This material is probably combustible.
[Ingestion]

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
[Inhalation]

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
[Skin]

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
[Eyes]

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
[Storage]

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
[Handling]

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
[Ingestion]

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
[Inhalation]

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
[Skin]

May cause skin irritation.
[Eyes]

May cause eye irritation.
[Hazards]

Contact with metals may evolve flammable hydrogen gas.
[EC Risk Phrase]

R 25 63
[EC Safety Phrase]

S 22 36/37 45
[UN (DOT)]

2811
[Personal Protection]

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
[Respirators]

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.
[Appearance]

Odorless or almost odorless pale yellow crystalline powder.
[Solubility in water]

Soluble
[Melting Point]

>360
[Boiling Point]

123 (29 torr)
[pKa/pKb]

7.44 (pKa)
[Partition Coefficient]

-.07
[Usage]

6-Thioguanine resistance is used as genetic markers for mutagen screening chinese hamster cells v-79 are described as convenient systems for detection of mutagens in vitro & in situ.
[Product Name]

6-Thioguanine
[Synonyms]

2-Amino-3,7-dihydropurine-6-thione
2-Amino-6-mercaptopurine
2-Amino-6-purinethiol
2-Amino-9H-purine-6(1H)-thione
6-Thioguanine
[CAS]

"CASEN_154-42-7.htm">154-42-7
[Formula]

C5H5N5S
[Molecular Weight]

167.19
[EINECS]

205-827-2
[RTECS]

UP0740000
[RTECS Class]

Drug; Mutagen; Reproductive Effector; Primary Irritant
[Merck]

12,9473
[Beilstein/Gmelin]

157765
[Beilstein Reference]

4-26-00-03926
[Small spills/leaks]

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.
[Incompatibilities]

Oxidizing agents.
[Stability]

Stable under normal temperatures and pressures.
[Decomposition]

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
[Combustion Products]

Fire may produce irritating, corrosive and/or toxic gases.
[UN Number]

2811
[Hazard Class]

6.1
[Packing Group]

I; II; III