| [Fire Fighting] Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. | |
| [Fire Potential] This material is probably combustible. | |
| [Ingestion] If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital. | |
| [Inhalation] IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used. | |
| [Skin] IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. | |
| [Eyes] First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. | |
| [Storage] Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage. | |
| [Handling] All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood. | |
| [Ingestion] See inhalation. | |
| [Inhalation] Symptoms of exposure to this compound may include bone-marrow suppression; delayed onset of leukopenia and thrombocytopenia; cytotoxic effects on the liver, kidneys and central nervous system; nausea; vomiting; flushing of the skin; esophagitis; diarrhea; dyspnea and hepatotoxicity. | |
| [Skin] See inhalation. | |
| [Eyes] See inhalation | |
| [Personal Protection] Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | |
| [Respirators] Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter). | |
| [Appearance] Orange-yellow solid. | |
| [Solubility in water] Slightly soluble | |
| [Melting Point] 30-32 | |
| [Boiling Point] 404 | |
| [pKa/pKb] 10.19 (pKa) | |
| [Partition Coefficient] 1.11 | |
| [Usage] A mustard gas-related -chloro-nitrosourea compound used as an alkylating agent in chemotherapy. It is used in the treatment of several types of brain cancer (including glioma, glioblastoma multiforme, medulloblastoma and astrocytoma), multiple myeloma and lymphoma (hodgkin's and non-hodgkin). . | |
| [Product Name] 1,3-Bis(2-chloroethyl)-1-nitrosourea | |
| [Synonyms] 1,3-Bis(2-chloroethyl)-1-nitrosourea BCNU Carmustine Gliadel Nitrumon NSC 409962 | |
| [CAS] "CASEN_154-93-8.htm">154-93-8 | |
| [Formula] C5H9Cl2N3O2 | |
| [Molecular Weight] 214.05 | |
| [EINECS] 205-838-2 | |
| [RTECS] YS2625000 | |
| [RTECS Class] Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data | |
| [Merck] 12,1894 | |
| [Beilstein/Gmelin] 2049744 | |
| [Small spills/leaks] Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. | |
| [Stability] No data. |
Print